• Cardiac adaptation to hypertension in adult female Dahl salt-sensitive rats is dependent on ovarian function, but loss of ovarian function does not predict early maladaptation 

      Ludvigsen, Stian; Mancusi, Costantino; Kildal, Simon; de Simone, Giovanni; Gerdts, Eva; Ytrehus, Kirsti (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-08)
      Aim of study was to examine experimentally the adult female hypertensive heart in order to determine the role of ovary function in the response of the heart to salt-dependent hypertension. Dahl salt-sensitive rats, age 12 weeks, with/without ovariectomy were fed a standard (0.3% NaCl) or high-salt diet (8%) for 16 weeks. Mean arterial blood pressure monitored noninvasively in conscious state ...
    • Gender differences in hearts subjected to decreased NO-production and elevated blood pressure 

      Kildal, Simon; Ludvigsen, Stian; Norvik, Jon Viljar; Johansen, David; Ytrehus, Kirsti (Master thesis; Mastergradsoppgave, 2016-10-31)
      Hypertension is one of the most important risk factors for heart failure in the general population. Hypertensive heart failure is associated with heart failure with preserved ejection fraction (HFpEF). Women have an increase proportion of HFpEF compared to men. Endothelial dysfunction thereby reduced NO production is proposed to play an important role in the pathophysiology of HFpEF. A suggested ...
    • Insidens av atrieflimmer i Tromsøundersøkelsen 1986-2011 

      Kildal, Simon (Master thesis; Mastergradsoppgave, 2016-05-30)
      Atrieflimmer (AF) er den vanligste arytmien i hjertet. Den har sitt utspring i atriene, og er derfor klassifisert som en supraventrikulær arytmi. Tidligere studier har vist at AF har en klar sammenheng med økende alder, og at menn har hyppigere insidens enn kvinner. I denne oppgaven ønsket vi å studere hvordan insidensen av AF i Tromsøundersøkelsen forandret seg fra 1986 til 2011. Vi ønsket også å ...
    • Sex-specific time trends in incident atrial fibrillation and the contribution of risk factors: the Tromsø Study 1994-2016 

      Sharashova, Ekaterina; Gerdts, Eva; Ball, Jocasta; Espnes, Hilde; Jacobsen, Bjarne K.; Kildal, Simon; Mathiesen, Ellisiv B.; Njølstad, Inger; Rosengren, Annika; Schirmer, Henrik; Wilsgaard, Tom; Løchen, Maja-Lisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-14)
      Aims To explore sex-specific time trends in atrial fibrillation (AF) incidence and to estimate the impact of changes in risk factor levels using individual participant-level data from the population-based Tromsø Study 1994–2016.<p> <p>Methods and results A total of 14 818 women and 13 225 men aged 25 years or older without AF were enrolled in the Tromsø Study between 1994 and 2008 and followed ...